Protective Effect of Tea Catechins on the DNA Scission Induced in Tritiated Water

Y. Ohashi; M. Konishi; H. Yoshioka; K. Yoshinaga; H. Yoshioka

doi:dx.doi.org/10.13182/FST02-A22627

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Protective Effect of Tea Catechins on the DNA Scission Induced in Tritiated Water

Y. Ohashi, M. Konishi, H. Yoshioka, K. Yoshinaga, H. Yoshioka

Fusion Science and Technology / Volume 41 / Number 3P2 / May 2002 / Pages 437-441

Biology / Proceedings of the Sixth International Conference on Tritium Science and Technology Tsukuba, Japan November 12-16, 2001 / dx.doi.org/10.13182/FST02-A22627

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The protecting effect of (−)-epicatechin (EC), (−)-epicatechin gallate (ECg), (−)-epigallocatechin (EGC), (−)-epigallocatechin gallate (EGCg) and 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) on the DNA strand scission induced in tritiated water was analyzed. The scission with the hydroxyl radical produced by the decomposition of water molecules was decreased by the addition of above reagents. Protective effect of EGCg, EC and DMPO was dependent on their concentrations, but that of ECg and EGC was independent. Therefore, it was considered that certain amounts of ECg, EGC molecules might locate around DNA molecules, interacting with DNA.